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Cover Picture: Biocatalytic Imine Reduction and Reductive Amination of Ketones (Adv. Synth. Catal. 8/2015)
Author(s) -
Schrittwieser Joerg H.,
Velikogne Stefan,
Kroutil Wolfgang
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500420
Subject(s) - reductive amination , chemistry , biocatalysis , imine , amination , amine gas treating , organic chemistry , combinatorial chemistry , transfer hydrogenation , catalysis , reaction mechanism , ruthenium
Biocatalytic imine reduction: Recent years have seen impressive progress in the biocatalytic asymmetric reduction of imines and reductive amination of ketones. Several new classes of enzymes have been introduced for these reactions, such as amine dehydrogenases, imine reductases, and artificial transfer hydrogenases. The front cover picture shows a selection of products accessible via biocatalytic CN reduction – including amino acid conjugates and natural alkaloids – along with a reductive‐amination biocatalyst, an opine dehydrogenase (artwork designed by Verena A. Resch). Details can be found in the review on pages 1655–1685 (J. H. Schrittwieser, S. Velikogne, W. Kroutil, Adv. Synth. Catal. 2015, 357, 1655–1685; DOI: 10.1002/adsc.201500213 ).