Premium
The Squaramide‐Catalyzed 1,3‐Dipolar Cycloaddition of Nitroalkenes with N ‐2,2,2‐Trifluoroethylisatin Ketimines: An Approach for the Synthesis of 5′‐Trifluoromethyl‐spiro[pyrrolidin‐3,2′‐oxindoles]
Author(s) -
Sun Quantao,
Li Xiaoyuan,
Su Jinhuan,
Zhao Long,
Ma Mingxia,
Zhu Yuanyuan,
Zhao Yanyan,
Zhu Ranran,
Yan Wenjin,
Wang Kairong,
Wang Rui
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500416
Subject(s) - squaramide , chemistry , cinchona , cycloaddition , trifluoromethyl , 1,3 dipolar cycloaddition , catalysis , enantioselective synthesis , organocatalysis , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , alkyl
A Cinchona alkaloid‐derived squaramide‐catalyzed asymmetric cycloaddition of trfluoromethyl‐containing azomethine ylides with β‐nitroalkenes was realized under mild conditions. A series of biologically important 5′‐trifluoromethyl‐ spiro[pyrrolidin‐3,2′‐oxindoles] was synthesized efficiently by this process in excellent yields, enantioseletivities and diastereoselectivities.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom