Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines  via  a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence | Zendy

Wang Chan | Zendy; Huang Kaimeng | Zendy; Wang Junying | Zendy; Wang Hongkai | Zendy; Liu Lingyan | Zendy; Chang Weixing | Zendy; Li Jing | Zendy

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Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence

Author(s) -

Wang Chan,

Huang Kaimeng,

Wang Junying,

Wang Hongkai,

Liu Lingyan,

Chang Weixing,

Li Jing

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500350

Subject(s) - hydroamination , sonogashira coupling , chemistry , intramolecular force , aryl , sequence (biology) , palladium , combinatorial chemistry , catalysis , pyrrole , organic chemistry , photochemistry , biochemistry , alkyl

A one‐pot reaction of homopropargylic amines and aryl iodides was developed in the presence of a palladium (Pd) catalyst and generated a series of tetrasubstituted pyrrole derivatives in good to high yields. This process involved a Sonogashira, intramolecular hydroamination, cyclization and oxidation sequence of reactions.

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