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Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence
Author(s) -
Wang Chan,
Huang Kaimeng,
Wang Junying,
Wang Hongkai,
Liu Lingyan,
Chang Weixing,
Li Jing
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500350
Subject(s) - hydroamination , sonogashira coupling , chemistry , intramolecular force , aryl , sequence (biology) , palladium , combinatorial chemistry , catalysis , pyrrole , organic chemistry , photochemistry , biochemistry , alkyl
Abstract A one‐pot reaction of homopropargylic amines and aryl iodides was developed in the presence of a palladium (Pd) catalyst and generated a series of tetrasubstituted pyrrole derivatives in good to high yields. This process involved a Sonogashira, intramolecular hydroamination, cyclization and oxidation sequence of reactions.