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Alkylations of Arylboronic Acids including Difluoroethylation/Trifluoroethylation via Nickel‐Catalyzed Suzuki Cross‐Coupling Reaction
Author(s) -
Zhang Xiaofei,
Yang Chunhao
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500346
Subject(s) - chemistry , nickel , halide , catalysis , aryl , alkylation , alkyl , functional group , suzuki reaction , combinatorial chemistry , coupling reaction , organic chemistry , polymer
An efficient alkylation method of functionalized alkyl halides under mild nickel‐catalyzed C( sp 3 )C( sp 2 ) Suzuki cross‐coupling conditions is described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel‐catalyzed direct 2,2‐difluoroethylation or 2,2,2‐trifluoroethylation of aryl‐/heteroarylboronic acids.