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Asymmetric Bromine–Lithium Exchange: Application toward the Synthesis of New Biaryl‐Diphosphine Ligands
Author(s) -
Graff Julien,
Łastawiecka Elżbieta,
Guénée Laure,
Leroux Frédéric,
Alexakis Alexandre
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500323
Subject(s) - desymmetrization , bromine , lithium (medication) , chemistry , combinatorial chemistry , biphenyl , catalysis , stereochemistry , enantioselective synthesis , organic chemistry , biology , endocrinology
The desymmetrization of the prochiral tetrabromobiphenyl via asymmetric bromine–lithium exchange as a key step of synthesis of novel biphenyl‐diphosphine ligands is reported. This new approach allows an easy access to twelve new enantiomerically pure atropisomeric ligands in one‐ to three‐step reactions in good to excellent yields.