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Exploiting Enzymatic Dynamic Reductive Kinetic Resolution (DYRKR) in Stereocontrolled Synthesis
Author(s) -
Applegate Gregory A.,
Berkowitz David B.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500316
Subject(s) - kinetic resolution , chemistry , scope (computer science) , stereocenter , organic synthesis , biocatalysis , enzyme , combinatorial chemistry , biochemical engineering , enzyme catalysis , nanotechnology , enantioselective synthesis , organic chemistry , catalysis , computer science , reaction mechanism , materials science , engineering , programming language
Over the past two decades, the domains of both frontline synthetic organic chemistry and process chemistry have seen an increase in crosstalk between asymmetric organic/organometallic approaches and enzymatic approaches to stereocontrolled synthesis. This review highlights the particularly auspicious role for dehydrogenase enzymes in this endeavor, with a focus on dynamic reductive kinetic resolutions (DYRKR) to “deracemize” building blocks, often setting two stereocenters in so doing. The scope and limitations of such dehydrogenase‐mediated processes are overviewed, as are future possibilities for the evolution of enzymatic DYRKR.