Premium
Rhodium(I)‐Catalyzed Intermolecular Hydroacylation of α‐Keto Amides and Isatins with Non‐Chelating Aldehydes
Author(s) -
Kou Kevin G. M.,
Longobardi Lauren E.,
Dong Vy M.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500313
Subject(s) - hydroacylation , chemistry , rhodium , phosphine , denticity , chelation , ligand (biochemistry) , catalysis , intermolecular force , ketone , organic chemistry , medicinal chemistry , metal , molecule , biochemistry , receptor
The application of the bidentate, electron‐rich bisphosphine ligand, 1,3‐bis(dicyclohexyl)phosphine‐propane (dcpp), in rhodium(I)‐catalyzed intermolecular ketone hydroacylation is herein described. Isatins and α‐keto amides are shown to undergo hydroacylation with a variety of non‐chelating linear and branched aliphatic aldehydes. Also reported is the synthesis of new bidentate chiral phosphine ligands, and their application in hydroacylation is discussed.