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Oxidative Coupling between Methylarenes and Ammonia: A Direct Approach to Aromatic Primary Amides
Author(s) -
Zhao Zhenguang,
Wang Tao,
Yuan Lin,
Hu Xu,
Xiong Fei,
Zhao Junfeng
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500310
Subject(s) - chemistry , primary (astronomy) , ammonia , oxidative coupling of methane , catalysis , aqueous solution , oxidative phosphorylation , chloride , iodide , organic chemistry , surface modification , coupling (piping) , combinatorial chemistry , mechanical engineering , biochemistry , physics , astronomy , engineering
A direct oxidative amidation between methylarenes and aqueous ammonia using a tert ‐butyl hydroperoxide and tetrabutylammonium iodide (TBHP/TBAI) oxidation system with co‐catalysis of iron(III) chloride has been developed. Both coupling partners were used in their native form to render prior functionalization unnecessary and afford a facile approach to aromatic primary amides.