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Nickel‐ or Cobalt‐Catalyzed Cross‐Coupling of Arylsulfonic Acid Salts with Grignard Reagents
Author(s) -
Malapit Christian A.,
Visco Michael D.,
Reeves Jonathan T.,
Busacca Carl A.,
Howell Amy R.,
Senanayake Chris H.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500304
Subject(s) - chemistry , cobalt , catalysis , nickel , tricyclohexylphosphine , reagent , electrophile , grignard reaction , organic chemistry , medicinal chemistry , polymer chemistry , inorganic chemistry , phosphine
The use of arylsulfonic acid salts as electrophiles in a nickel‐ or cobalt‐catalyzed cross‐coupling with Grignard reagents is described. Bis(tricyclohexylphosphine)nickel dichloride [NiCl 2 (PCy 3 ) 2 ] was found to be the optimal catalyst, and reactions with this catalyst proceeded in most cases at room temperature. The analogous cobalt catalyst [CoCl 2 (PCy 3 ) 2 ] was also found to promote the cross‐coupling reaction at higher temperature (60 °C).
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