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Metal‐Free Oxidative Decarbonylative Coupling of Aliphatic Aldehydes with Azaarenes: Successful Minisci‐Type Alkylation of Various Heterocycles
Author(s) -
Tang RenJin,
Kang Lei,
Yang Luo
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500268
Subject(s) - chemistry , regioselectivity , alkylation , substrate (aquarium) , metal , organic chemistry , combinatorial chemistry , catalysis , oceanography , geology
A metal‐free oxidative decarbonylative coupling of aliphatic aldehydes with various electron‐deficient heterocycles has been developed. This reaction is supposed to be realized via a Minisci‐type mechanism, based on the substrate scope, regioselectivity and radical trapping experiments. The ready availability of aliphatic aldehydes, metal‐free conditions and broad substrate scope should make this method attractive for the late‐stage alkylation of bioactive heterocycles.