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Copper‐Catalyzed Aryltrifluoromethylation of N ‐Phenylcinnamamides: Access to Trifluoromethylated 3,4‐Dihydroquinolin‐2(1 H )‐ones
Author(s) -
Wang Qiang,
Han Guifang,
Liu Yuxiu,
Wang Qingmin
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500261
Subject(s) - chemistry , regioselectivity , copper , catalysis , combinatorial chemistry , medicinal chemistry , organic chemistry , stereochemistry
A method for copper‐catalyzed aryltrifluoromethylation of N ‐phenylcinnamamides is reported. This method provides a straightforward route to a variety of CF 3 ‐containing 3,4‐dihydroquinolin‐2(1 H )‐ones with excellent regioselectivity and diastereoselectivity.