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Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐ N ‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2,3,6,7‐Tetrahydro‐1 H ‐pyrrolo[3,2‐ c ]pyridin‐4(5 H )‐ones
Author(s) -
Zhang Zhiguo,
Zhang Feisong,
Wang Huanhuan,
Wu Hao,
Duan Xinyu,
Liu Qingfeng,
Liu Tongxin,
Zhang Guisheng
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500251
Subject(s) - chemistry , domino , catalysis , cascade reaction , acryloyl chloride , ring (chemistry) , reaction conditions , michael reaction , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , acrylate , polymer , monomer
A facile one‐pot, catalyst‐free reaction has been developed for the synthesis of 2,3,6,7‐tetrahydro‐1 H ‐pyrrolo[3,2‐ c ]pyridin‐4(5 H )‐ones from readily available 1‐acryloyl‐1‐ N ‐arylcarbamylcyclopropanes and amines using a domino ring‐opening/cyclization/aza‐addition sequence.