Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐ N ‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2,3,6,7‐Tetrahydro‐1 H ‐pyrrolo[3,2‐ c ]pyridin‐4(5 H )‐ones | Zendy

Zhang Zhiguo | Zendy; Zhang Feisong | Zendy; Wang Huanhuan | Zendy; Wu Hao | Zendy; Duan Xinyu | Zendy; Liu Qingfeng | Zendy; Liu Tongxin | Zendy; Zhang Guisheng | Zendy

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Catalyst‐Free Domino Reaction of 1‐Acryloyl‐1‐ N ‐arylcarbamylcyclopropanes with Amines: One‐Pot Approach to 2,3,6,7‐Tetrahydro‐1 H ‐pyrrolo[3,2‐ c ]pyridin‐4(5 H )‐ones

Author(s) -

Zhang Zhiguo,

Zhang Feisong,

Wang Huanhuan,

Wu Hao,

Duan Xinyu,

Liu Qingfeng,

Liu Tongxin,

Zhang Guisheng

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201500251

Subject(s) - chemistry , domino , catalysis , cascade reaction , acryloyl chloride , ring (chemistry) , reaction conditions , michael reaction , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , acrylate , polymer , monomer

A facile one‐pot, catalyst‐free reaction has been developed for the synthesis of 2,3,6,7‐tetrahydro‐1 H ‐pyrrolo[3,2‐ c ]pyridin‐4(5 H )‐ones from readily available 1‐acryloyl‐1‐ N ‐arylcarbamylcyclopropanes and amines using a domino ring‐opening/cyclization/aza‐addition sequence.

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