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3‐Naphthylindole Construction by Rhodium(II)‐Catalyzed Regioselective Direct Arylation of Indoles with 1‐Diazonaphthalen‐2‐(1 H )‐ones
Author(s) -
Baral Ek Raj,
Lee Yong Rok,
Kim Sung Hong
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500209
Subject(s) - regioselectivity , chemistry , rhodium , benzofuran , pyrrole , catalysis , yield (engineering) , furan , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy
The regioselective direct 3‐arylation of indoles with 1‐diazonaphthalen‐2‐(1 H )‐ones was developed by means of a rhodium(II) pivalate‐catalyzed cross‐coupling reaction. This procedure provided a variety of novel 3‐naphthylindoles in high yield. The direct coupling of benzofuran, pyrrole or furan with 1‐diazonaphthalen‐2‐(1 H )‐ones afforded 2‐ or 3‐naphthyl substituted heterocycles.