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Selective Oxidation of Amines to Aldehydes or Imines using Laccase‐Mediated Bio‐Oxidation
Author(s) -
Galletti Paola,
Funiciello Federica,
Soldati Roberto,
Giacomini Daria
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500165
Subject(s) - chemistry , laccase , biocatalysis , trametes versicolor , aqueous solution , selectivity , organic chemistry , primary (astronomy) , redox , combinatorial chemistry , enzyme , catalysis , reaction mechanism , physics , astronomy
An efficient and practical chemo‐enzymatic aerobic oxidation in water of benzylamines to obtain aldehydes or imines is described. Laccase from Trametes versicolor was chosen as biocatalyst, and TEMPO (radical 2,2,6,6‐tetramethylpiperidine 1‐oxyl) as mediator. A study on the pH dependence of the aqueous medium allowed us to realise a fine tuning on product selectivity. Under our optimized reaction conditions, the bio‐oxidation of a series of primary, secondary and cyclic amines has been achieved.