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Enantioselective Addition of Heteroarylboronates to Arylimines Catalyzed by a Rhodium‐Diene Complex
Author(s) -
Chen YaJing,
Cui Zhe,
Feng ChenGuo,
Lin GuoQiang
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500147
Subject(s) - rhodium , chemistry , diene , enantioselective synthesis , catalysis , aryl , reactivity (psychology) , organic chemistry , combinatorial chemistry , medicinal chemistry , reaction conditions , medicine , alkyl , natural rubber , alternative medicine , pathology
An enantioselective rhodium‐catalyzed 1,2‐addition of heteroarylboronates to aryl N ‐tosylimines and N ‐nosylimines has been developed. Our chiral rhodium‐diene catalyst showed high efficiency in the stereochemical control of this reaction. Under the optimal reaction conditions, a variety of boronates bearing pyridinyl, furyl or thienyl groups were successfully reacted with aryl imines. The boronate type, with balance of the stability and reactivity, is critical for achieving high reaction yields in this reaction.