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Direct ortho ‐Hydroxylation of 2‐Phenylpyridines using Palladium(II) Chloride and Hydrogen Peroxide
Author(s) -
Yamaguchi Tomoaki,
Yamaguchi Eiji,
Tada Norihiro,
Itoh Akichika
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500061
Subject(s) - chemistry , hydrogen peroxide , hydroxylation , palladium , aqueous solution , chloride , phenol , peroxide , hydrogen bond , photochemistry , inorganic chemistry , catalysis , organic chemistry , molecule , enzyme
Direct functionalization of the ubiquitous CH bond is receiving much attention because complex structures can be formed from simple precursors. This paper reports a useful method for the direct hydroxylation of 2‐phenylpyridines using palladium(II) chloride and aqueous hydrogen peroxide. In this method, hydrogen peroxide, which has high atom efficiency, is employed as the oxidant and phenol derivatives are generated via CH activation.