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Inside Cover: Biotransformation of Linoleic Acid into Hydroxy Fatty Acids and Carboxylic Acids Using a Linoleate Double Bond Hydratase as Key Enzyme (Adv. Synth. Catal. 2‐3/2015)
Author(s) -
Oh HyeJin,
Kim SaeUm,
Song JiWon,
Lee JungHoo,
Kang WooRi,
Jo YeSeul,
Kim KyoungRok,
Bornscheuer Uwe T.,
Oh DeokKun,
Park JinByung
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500036
Subject(s) - chemistry , double bond , biocatalysis , biotransformation , enzyme , carboxylic acid , stereochemistry , linoleic acid , fatty acid , isomerization , organic chemistry , catalysis , reaction mechanism
The inside cover picture , by D.‐K. Oh, J.‐B. Park and co‐workers, illustrates the cloning and reaction of linoleate double bond hydratases of Lactobacillus acidophilus. The enzymes were highly specific for the hydration of the C‐9 or the C‐12 double bond of unsaturated fatty acids. Thereby, C‐10 or C‐13 hydroxy fatty acids could be selectively produced. In addition, the hydroxy fatty acids were further converted into industrially relevant carboxylic acids (e.g., 12‐hydroxy‐ cis ‐9‐dodecenoic acid, α,ω‐tridec‐9‐enedioic acid) and lactones (i.e., δ‐decalactone, γ‐dodecelactone) via whole‐cell biocatalysis. Details of this work can be found in the full paper on pages 408‐416 (H.‐J. Oh, S.‐U. Kim, J.‐W. Song, J.‐H. Lee, W.‐R. Kang, Y.‐S. Jo, K.‐R. Kim, U. T. Bornscheuer, D.‐K. Oh, J.‐B. Park, Adv. Synth. Catal. 2015, 357, 408–416; DOI: 10.1002/adsc.201400893 ).