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CN Coupling of Indoles and Carbazoles with Aromatic Chlorides Catalyzed by a Single‐Component NHC‐Nickel(0) Precursor
Author(s) -
Rull Silvia G.,
Blandez Juan F.,
Fructos Manuel R.,
Belderrain Tomás R.,
Nicasio M. Carmen
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500030
Subject(s) - chemistry , nickel , halide , catalysis , aryl , component (thermodynamics) , combinatorial chemistry , organic chemistry , reaction conditions , alkyl , physics , thermodynamics
A new and efficient nickel‐based protocol for the N ‐arylation of indoles and carbazoles with aromatic chlorides, the least expensive of the aryl halides, is described. The procedure provides selectively N ‐(hetero)arylation products in good to high yields, in short reaction times and without adding an excess of ligands.