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Cover Picture: Minutes Synthesis of 1,4,5‐Trisubstituted 5‐Dialkylamino‐1,2,3‐triazoles by 1‐Copper(I)‐Alkyne Controlled Tandem Process (Adv. Synth. Catal. 2‐3/2015)
Author(s) -
Wang Bo,
Liu Nan,
Chen Wenwen,
Huang Dayun,
Wang Xinyan,
Hu Yuefei
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201500023
Subject(s) - alkyne , chemistry , cycloaddition , azide , copper , tandem , electrophile , front cover , combinatorial chemistry , stereochemistry , cover (algebra) , organic chemistry , catalysis , materials science , composite material , mechanical engineering , engineering
The front cover picture , provided by Bo Wang, Xinyan Wang, and Yuefei Hu, illustrates the characteristics of 1‐copper(I)‐2‐phenylethyne in its preparation, properties and structure. By using its polymeric structure, the tandem reaction sequence of 1‐Cu(I)‐alkyne with an azide (cycloaddition) and then an electrophile E+ (electrophilic substitution) can be controlled efficiently. Thus, a general method for the synthesis of 1,4,5‐trisubstituted 1,2,3‐triazoles was developed by simply stirring the mixture of a 1‐copper(I)‐alkyne, an azide and an electroplile E+. Details can be found in the full paper on pages 401–407 (B. Wang, N. Liu, W. Chen, D. Huang, X. Wang, Y. Hu, Adv. Synth. Catal. 2015, 357, 401–407; DOI: 10.1002/adsc.201400471 ).