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Very Important Publication: Iridium‐Catalyzed Intramolecular Enantioselective CH Alkylation at the C‐2 Position of N ‐Alkenylindoles
Author(s) -
Shibata Takanori,
Ryu Naoto,
Takano Hideaki
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401163
Subject(s) - enantioselective synthesis , chemistry , iridium , intramolecular force , alkylation , cationic polymerization , catalysis , medicinal chemistry , stereochemistry , bond cleavage , ligand (biochemistry) , yield (engineering) , cleavage (geology) , organic chemistry , receptor , biochemistry , materials science , geotechnical engineering , fracture (geology) , engineering , metallurgy
Intramolecular enantioselective alkylation of N ‐alkenylindoles proceeded via CH bond cleavage at the C‐2 position in the presence of a cationic iridium catalyst with a diphosphine ligand. Aroyl groups at the C‐3 position of the indoles operated as effective directing groups, and chiral 1‐substituted‐2,3‐dihydro‐1 H ‐pyrrolo[1,2‐ a ]indoles were obtained in high yield with excellent ee .