Brønsted Acid‐Catalyzed Enantioselective Synthesis of Isatin‐ Derived  N , S ‐Acetals | Zendy

Beceño Christian | Zendy; Chauhan Pankaj | Zendy; Rembiak Andreas | Zendy; Wang Ai | Zendy; Enders Dieter | Zendy

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Brønsted Acid‐Catalyzed Enantioselective Synthesis of Isatin‐ Derived N , S ‐Acetals

Author(s) -

Beceño Christian,

Chauhan Pankaj,

Rembiak Andreas,

Wang Ai,

Enders Dieter

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201401155

Subject(s) - isatin , chemistry , enantioselective synthesis , enantiopure drug , brønsted–lowry acid–base theory , phosphoric acid , nucleophile , catalysis , organocatalysis , organic chemistry , combinatorial chemistry

The enantioselective organocatalytic nucleophilic addition of thiols to isatin‐derived ketimines has been developed utilizing only 1 mol% of an enantiopure BINOL‐derived phosphoric acid. The new protocol provides a series of isatin‐derived N , S ‐acetals in high yields (up to 98%) and high enantioselectivities (up to 93% ee ).

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