Premium
Palladium‐Catalyzed One‐Pot Sonogashira Coupling, exo ‐ dig Cyclization and Hydride Transfer Reaction: Synthesis of Pyridine‐Substituted Pyrroles
Author(s) -
Shekarrao Kommuri,
Kaishap Partha Pratim,
Gogoi Sanjib,
Boruah Romesh C.
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401117
Subject(s) - sonogashira coupling , chemistry , pyridine , catalysis , palladium , dig , hydride , combinatorial chemistry , coupling reaction , alkylation , medicinal chemistry , organic chemistry , hydrogen , computer security , computer science
An efficient palladium(II)‐catalyzed method for the synthesis of alkylated pyridine‐substituted pyrroles has been developed by a one‐pot three component reaction of β ‐bromovinyl aldehydes, primary amines and 2‐alkynylpyridines in good yields. The reactions can also provide an efficient route to 2‐picolinoylpyrroles by slightly altering the reaction conditions.