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Phenyliodine Diacetate‐Mediated Intramolecular C( sp 2 )H Amidation for 1,2‐Disubstituted Benzimidazole Synthesis under Metal‐Free Conditions
Author(s) -
Maiti Saikat,
Mal Prasenjit
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401110
Subject(s) - chemistry , hypervalent molecule , intramolecular force , benzimidazole , reagent , environmentally friendly , transition metal , metal , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , catalysis , ecology , biology
A transition metal‐free, hypervalent iodine(III) reagent [phenyliodine diacetate (PIDA)]‐mediated C( sp 2 )H amidation in trifluoroethanol (TFE) has been developed. The intramolecular coupling methodology presented here provides a direct access to 1,2‐disubstituted multifunctional benzimidazoles in good to excellent yields. The reactions were performed in the open air and at ambient temperature, and were found to be eco‐friendly and atom‐economical.