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Inside Cover: Increasing the Reactivity of Amides towards Organometallic Reagents: An Overview (Adv. Synth. Catal. 18/2014)
Author(s) -
Pace Vittorio,
Holzer Wolfgang,
Olofsson Berit
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401093
Subject(s) - chemistry , iminium , nucleophile , electrophile , reagent , trifluoromethanesulfonate , organic chemistry , reactivity (psychology) , combinatorial chemistry , ion , catalysis , medicine , alternative medicine , pathology
The inside cover picture , provided by Vittorio Pace, Wolfgang Holzer, and Berit Olofsson, illustrates reactions of amides with organometallic reagents. The nucleophilic addition of carbon nucleophiles to amides would be an efficient approach to access ketones or amines, but the low electrophilicity of amides has made these transformations challenging for synthetic chemists. In recent years, several novel concepts have been developed where amides are transformed into highly electrophilic imidoyl triflate and iminium ions, N ‐alkoxyamides or thioamides. Addition of organometallics to these species chemoselectively delivers amines or ketones. Details of this work can be found in the review on pages 3697–3736 (V. Pace, W. Holzer, B. Olofsson, Adv. Synth. Catal. 2014, 356, 3697–3736; DOI: 10.1002/adsc.201400630 ).