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Iron‐Catalyzed Direct Synthesis of Amides from Methylarenes
Author(s) -
Srinivas Kotha Surya,
Badigenchala Sindhura,
Sekar Govindasamy
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401086
Subject(s) - chemistry , catalysis , amide , aldehyde , organic chemistry , oxidative phosphorylation , combinatorial chemistry , biochemistry
An efficient, green and first catalytic process has been developed for the direct synthesis of amides from readily available petroleum by‐products (methylarenes) and amines using an iron catalyst. In this new catalytic reaction, the methyl group of the methylarene is oxidized to the corresponding aldehyde through non‐directed C ( sp 3 ) H oxidation followed by its oxidative amidation with N ‐chloroamine, yielding the carboxylic amide. Oxidation with an iron catalyst, tert ‐butyl hydroperoxide (TBHP) as sole oxidant, the synthesis of amides under mild reaction conditions and the utilization of methylarenes as starting material make this methodology novel and environmentally benign.