N‐Heterocyclic Carbene‐Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin‐3‐ones with a Tetrasubstituted Carbon Stereocenter | Zendy

Xu Junyu | Zendy; Hu Shihe | Zendy; Lu Yingyan | Zendy; Dong Ying | Zendy; Tang Weifang | Zendy; Lu Tao | Zendy; Du Ding | Zendy

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N‐Heterocyclic Carbene‐Catalyzed Umpolung Formal [3+3] Cycloaddition of Enals with Isatogens: Access to Fused Indolin‐3‐ones with a Tetrasubstituted Carbon Stereocenter

Author(s) -

Xu Junyu,

Hu Shihe,

Lu Yingyan,

Dong Ying,

Tang Weifang,

Lu Tao,

Du Ding

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201401070

Subject(s) - stereocenter , umpolung , chemistry , indole test , carbene , catalysis , cycloaddition , combinatorial chemistry , carbon fibers , stereochemistry , organic chemistry , enantioselective synthesis , nucleophile , computer science , algorithm , composite number

A novel synthetic method to access fused indolin‐3‐ones with a tetrasubstituted carbon stereocenter has been developed via NHC‐catalyzed umpolung formal [3+3] cycloaddtion of enals with isatogens. This methodology could be also applied for the quick construction of the 6‐5‐5 tricyclic pyrrolo[1,2‐ a ]indole skeleton which is frequently found as a core structure of many indole alkaloids.

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