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Inside Cover: The Synthesis of Highly Active Iridium(I) Complexes and their Application in Catalytic Hydrogen Isotope Exchange (Adv. Synth. Catal. 17/2014)
Author(s) -
Brown Jack A.,
Cochrane Alison R.,
Irvine Stephanie,
Kerr William J.,
Mondal Bhaskar,
Parkinson John A.,
Paterson Laura C.,
Reid Marc,
Tuttle Tell,
Andersson Shalini,
Nilsson Göran N.
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401054
Subject(s) - chemistry , iridium , phosphine , catalysis , hydrogen isotope , hydrogen , selectivity , carbene , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
The inside cover picture, by Kerr and co‐workers, depicts a series of robust, yet highly active Ir(I) complexes bearing specifically encumbered N‐heterocyclic carbene and phosphine ligands. These complexes are extremely effective in hydrogen isotope exchange processes (with D or T), with low catalyst loadings, good levels of selectivity, and broad directing group applicability. The labelling of several complex drug molecules further highlights the catalysts utility. Mechanistic insight into the operation of these catalysts has also been provided by a combination of NMR and theoretical DFT studies. Details of this work can be found in the full paper on pages 3551–3562 (J. A. Brown, A. R. Cochrane, S. Irvine, W. J. Kerr, B. Mondal, J. A. Parkinson, L. C. Paterson, M. Reid, T. Tuttle, S. Andersson, G. N. Nilsson, Adv. Synth. Catal. 2014, 356, 3551–3562; DOI:10.1002/adsc.201400730) .