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Bifunctional Amine‐Squaramides: Powerful Hydrogen‐Bonding Organocatalysts for Asymmetric Domino/Cascade Reactions
Author(s) -
Chauhan Pankaj,
Mahajan Suruchi,
Kaya Uğur,
Hack Daniel,
Enders Dieter
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201401003
Subject(s) - squaramide , stereocenter , bifunctional , chemistry , domino , cascade reaction , organocatalysis , combinatorial chemistry , catalysis , thiourea , cascade , amine gas treating , enantioselective synthesis , stereoselectivity , organic chemistry , chromatography
Organocatalytic domino/cascade reactions provide a convenient method for the construction of complex molecular structures bearing multiple stereocenters in a highly stereoselective fashion. Among various organocatalysts, bifunctional squaramides have emerged as powerful hydrogen‐bonding catalysts for promoting a wide array of useful asymmetric organocascade sequences. Higher activity and ease of preparation make these catalysts excellent alternatives for thiourea‐based organocatalysts. This review highlights the advances in the rapidly growing field of amine‐squaramide‐catalyzed domino/cascade reactions and their mode of action.