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Synthesis and Biological Activity of 10‐Aza‐narciclasine
Author(s) -
Vshyvenko Sergey,
W'Giorgis Zemane,
Weber Audrey,
Neverova Natalia,
Hedberg Bradley,
Hudlicky Tomas
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400993
Subject(s) - chemistry , bromobenzene , intramolecular force , derivative (finance) , stereochemistry , heck reaction , combinatorial chemistry , organic chemistry , palladium , catalysis , financial economics , economics
The first active aza analogue of narciclasine was synthesized from a pentasubstituted derivative of nicotinic acid. The key features of the synthesis include a halogen dance of bromopyridine and an intramolecular Heck reaction with a conduramine derived chemoenzymatically from bromobenzene. 10‐Aza‐narciclasine was found to have reasonable activity against several cancer cell lines.