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Recent Advances in Transition Metal‐Catalyzed Methylation Reactions
Author(s) -
Yan Guobing,
Borah Arun Jyoti,
Wang Lianggui,
Yang Minghua
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400984
Subject(s) - chemistry , dimethyl sulfate , diazomethane , methylation , methyl iodide , reagent , catalysis , dimethyl carbonate , organic synthesis , hazardous waste , transition metal , combinatorial chemistry , organic chemistry , ecology , biochemistry , biology , gene
Abstract Methylation is one of the most fundamental synthetic transformations in organic chemistry, but usually employs hazardous and toxic reagents, such as methyl iodide, dimethyl sulfate, diazomethane and dimethyl carbonate. In order to address sustainable development and green strategies, synthetic chemists have devoted much effort to the discovery and development of new methylating reagents, which are successfully being applied in transition metal‐catalyzed cross‐coupling reactions. In this review, recent advances in this area are summarized, mainly including C ‐methylation, N ‐methylation and O ‐methylation. The respective reaction mechanisms are also discussed.