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Copper(II)‐Catalyzed Single‐Step Synthesis of Aryl Thiols from Aryl Halides and 1,2‐Ethanedithiol
Author(s) -
Liu Yajun,
Kim Jihye,
Seo Heesun,
Park Sunghyouk,
Chae Junghyun
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400941
Subject(s) - chemistry , aryl , reagent , halide , catalysis , combinatorial chemistry , organic chemistry , copper , functional group , alkyl , polymer
A highly efficient transition metal‐catalyzed single‐step synthesis of aryl thiols from aryl halides has been developed employing copper(II) catalyst and 1,2‐ethanedithiol. The key features are use of readily available reagents, a simple operation, and relatively mild reaction conditions. This new protocol shows a broad substrate scope with excellent functional group compatibility. A variety of aryl thiols are directly prepared from aryl halides in high yields. Furthermore, the aryl thiols are used in situ for the synthesis of more advanced molecules such as diaryl sulfides and benzothiophenes.