Premium
Two Consecutive Palladium(II)‐Promoted CH Alkenylation Reactions for the Synthesis of 3‐Alkenylquinolones
Author(s) -
OrtizdeElguea Verónica,
Sotomayor Nuria,
Lete Esther
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400931
Subject(s) - chemistry , intramolecular force , palladium , intermolecular force , catalysis , medicinal chemistry , combinatorial chemistry , atom (system on chip) , stereochemistry , organic chemistry , molecule , computer science , embedded system
Highly substituted quinolones are obtained through an efficient and atom economical procedure that involves two consecutive palladium(II)‐catalyzed CH alkenylation reactions. A selective 6‐ endo intramolecular CH alkenylation leads to 4‐substituted quinolones that have been further functionalized at C‐3 through a second intermolecular CH alkenylation reaction.