Premium
Gas–Liquid Segmented Flow Microfluidics for Screening Copper/TEMPO‐Catalyzed Aerobic Oxidation of Primary Alcohols
Author(s) -
Vanoye Laurent,
Pablos Mertxe,
de Bellefon Claude,
FavreRéguillon Alain
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400925
Subject(s) - chemistry , copper , microreactor , alcohol oxidation , catalysis , primary (astronomy) , alcohol , limiting , redox , microfluidics , mass transfer , combinatorial chemistry , organic chemistry , nanotechnology , chromatography , materials science , astronomy , mechanical engineering , physics , engineering
Aerobic oxidation using a combination of copper salts and 2,2,6,6‐tetramethylpiperidine N ‐oxyl (TEMPO) represent useful tools for organic synthesis and several closely related catalyst systems have been reported. To gain further insights, these catalytic systems were evaluated in a gas–liquid segmented flow device. The improvement of oxygen mass transfer has a significant influence on the turnover‐limiting step. Hence, an improved catalytic system using copper(II) as copper source was implemented in a microreactor for the safe and efficient oxidation of primary alcohol.