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Ruthenium(II)‐Catalyzed CH Arylation of Anilides with Boronic Acids, Borinic Acids and Potassium Trifluoroborates
Author(s) -
Hubrich Jonathan,
Himmler Thomas,
Rodefeld Lars,
Ackermann Lutz
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400906
Subject(s) - chemistry , ruthenium , catalysis , cationic polymerization , potassium , substrate (aquarium) , combinatorial chemistry , organic chemistry , oceanography , geology
An in situ generated cationic ruthenium(II) catalyst allowed for robust CH arylations of anilides with boronic acids. The optimized ruthenium catalyst was found to be both site selective and chemoselective, thereby providing the monoarylated products in excellent yields with ample substrate scope. The catalyst’s high efficacy furthermore set the stage for efficient CH arylations with borinic acids as well as potassium trifluoroborates.