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Utilizing Mor‐DalPhos/Palladium‐Catalyzed Monoarylation in the Multicomponent One‐Pot Synthesis of Indoles
Author(s) -
RottaLoria Nicolas L.,
Borzenko Andrey,
Alsabeh Pamela G.,
Lavery Christopher B.,
Stradiotto Mark
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400903
Subject(s) - chemistry , palladium , catalysis , inert gas , inert , acetone , alkyl , substrate (aquarium) , combinatorial chemistry , primary (astronomy) , organic chemistry , reaction conditions , oceanography , physics , astronomy , geology
The application of a Mor‐DalPhos/palladium catalyst system in the one‐pot, multicomponent assembly of substituted indoles from ortho ‐chlorohaloarenes, alkyl ketones (including acetone), and primary amines is reported. The described protocols offer improved substrate scope in all three reaction components, under more mild conditions and without the need for an additional drying agent. Also reported are the first examples of such multicomponent reactions where all reactants are combined at the start of the reaction, without the need for inert atmosphere reaction conditions.