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One‐Pot Synthesis of Symmetrical 2,6‐Diarylpyridines via Palladium/Copper‐Catalyzed Sequential Decarboxylative and Direct CH Arylation
Author(s) -
Ma Zhiyong,
Liu Hailong,
Zhang Chunchun,
Zheng Xueli,
Yuan Maolian,
Fu Haiyan,
Li Ruixiang,
Chen Hua
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400900
Subject(s) - chemistry , palladium , picolinic acid , copper , aryl , catalysis , decarboxylation , oxide , coupling (piping) , combinatorial chemistry , medicinal chemistry , organic chemistry , metallurgy , alkyl , materials science
A palladium(II)/copper oxide (Cu 2 O)‐catalyzed one‐pot decarboxylative and direct CH arylation of 2‐picolinic acid with aryl bromides has been developed. Various aryl bromides have been shown to be efficient coupling partners in the presence of dimethyl sulfate, furnishing symmetrical 2,6‐diarylpyridines in moderate to good yields.