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Ruthenium(II)‐Catalyzed Hydrogen Transfer/Annulation Cascade Processes between Alcohols and 2‐Nitrobenzaldehydes
Author(s) -
Li HuiJing,
Wang ChenChao,
Zhu Shuai,
Dai ChunYang,
Wu YanChao
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400898
Subject(s) - annulation , chemistry , ruthenium , catalysis , triphenylphosphine , transfer hydrogenation , hydrogen , cascade , photochemistry , medicinal chemistry , organic chemistry , combinatorial chemistry , chromatography
The synthesis of quinolines from alcohols and 2‐nitrobenzaldehydes is described. Unreactive alcohols and 2‐nitrobenzaldehydes were concurrently converted to the reactive reactants for a Friedländer annulation via a hydrogen transfer. Tris(triphenylphosphine)ruthenium(II) dichloride [Ru(PPh 3 ) 3 Cl 2 ] appeared to serve the dual role of an efficient hydrogen transfer catalyst and a suitable Friedländer annulation catalyst.