Potassium Iodide‐Catalyzed Three‐Component Synthesis of 2‐Arylquinazolines  via  Amination of Benzylic CH Bonds of Methylarenes | Zendy

Zhao Dan | Zendy; Shen Qi | Zendy; Li JianXin | Zendy

Premium

Potassium Iodide‐Catalyzed Three‐Component Synthesis of 2‐Arylquinazolines via Amination of Benzylic CH Bonds of Methylarenes

Author(s) -

Zhao Dan,

Shen Qi,

Li JianXin

Publication year - 2015

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400827

Subject(s) - chemistry , amination , iodide , catalysis , iodine , aldehyde , salt (chemistry) , aryl , ammonia , methyl iodide , potassium , organic chemistry , component (thermodynamics) , nitrogen , medicinal chemistry , combinatorial chemistry , alkyl , physics , thermodynamics

A novel potassium iodide‐catalyzed three‐component synthesis of quinazolines via benzylic CH bonds amination was developed. Commonly used ammonia salt and the sp 3 carbon in commercially available methylarenes were used as nitrogen and C 1 sources, respectively. Mechanistic studies indicated that an aryl aldehyde is involved as a key intermediate in the reaction.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research