Premium
Potassium Iodide‐Catalyzed Three‐Component Synthesis of 2‐Arylquinazolines via Amination of Benzylic CH Bonds of Methylarenes
Author(s) -
Zhao Dan,
Shen Qi,
Li JianXin
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400827
Subject(s) - chemistry , amination , iodide , catalysis , iodine , aldehyde , salt (chemistry) , aryl , ammonia , methyl iodide , potassium , organic chemistry , component (thermodynamics) , nitrogen , medicinal chemistry , combinatorial chemistry , alkyl , physics , thermodynamics
A novel potassium iodide‐catalyzed three‐component synthesis of quinazolines via benzylic CH bonds amination was developed. Commonly used ammonia salt and the sp 3 carbon in commercially available methylarenes were used as nitrogen and C 1 sources, respectively. Mechanistic studies indicated that an aryl aldehyde is involved as a key intermediate in the reaction.