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Rhodium(III)‐Catalyzed in situ Oxidizing Directing Group‐ Assisted CH Bond Activation and Olefination: A Route to 2‐Vinylanilines
Author(s) -
Muralirajan Krishnamoorthy,
Haridharan Radhakrishnan,
Prakash Sekar,
Cheng ChienHong
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400791
Subject(s) - chemistry , oxidizing agent , rhodium , catalysis , moiety , in situ , ketone , medicinal chemistry , group (periodic table) , functional group , double bond , organic chemistry , combinatorial chemistry , polymer
A new and efficient method for the synthesis of 2‐vinylanilines from the reaction of arylhydrazine hydrochlorides with alkenes and diethyl ketone via a rhodium‐catalyzed CH activation is described. The oxidant‐free olefination reaction involves the in situ generation of an NNCR 1 R 2 moiety as the oxidizing directing group thus providing an easy access to 2‐vinylanilines.