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N‐Heterocyclic Carbene‐Catalyzed Oxidative Amidation of Aldehydes with Amines
Author(s) -
Alanthadka Anitha,
Maheswari C. Uma
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400739
Subject(s) - chemistry , carbene , steric effects , catalysis , oxidative phosphorylation , organic chemistry , aryl , combinatorial chemistry , biochemistry , alkyl
The N‐heterocyclic carbene (NHC)‐catalyzed oxidative amidation of aromatic aldehydes with amines in the presence of N ‐bromosuccinimide (NBS) as an oxidant has been developed for the synthesis of amides. This amidation strategy is tolerant to both the electronic and the steric nature of the aryl aldehydes employed. The present methodology was extended to chiral amino acid derivatives to generate the corresponding amides in good yields and excellent ee values (>98%).