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Oxidative Alkenylation/Annulation of Benzimidates via Ruthenium(II)‐Catalyzed CH Activation to Generate 3‐Methyleneisoindolin‐1‐ones
Author(s) -
Li Xing Guang,
Sun Min,
Liu Kai,
Liu Pei Nian
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400727
Subject(s) - annulation , ruthenium , chemistry , catalysis , stereoselectivity , cascade , oxidative phosphorylation , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , chromatography
A novel ruthenium‐catalyzed oxidative alkenylation/annulation cascade reaction is described for synthesizing 3‐methyleneisoindolin‐1‐ones. In the protocol, the N H imidate is applied efficiently as a directing group in ruthenium‐catalyzed CH activation, generating various 3‐methyleneisoindolin‐1‐ones with high regio‐ and stereoselectivity in moderate to good yields.