Intermolecular Conjugate Addition of Pyrroloindoline and Furoindoline Radicals to α,β‐Unsaturated Enones  via  Photoredox Catalysis | Zendy

Zhou Shupeng | Zendy; Zhang Deliang | Zendy; Sun Yu | Zendy; Li Ruofan | Zendy; Zhang Wenhao | Zendy; Li Ang | Zendy

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Intermolecular Conjugate Addition of Pyrroloindoline and Furoindoline Radicals to α,β‐Unsaturated Enones via Photoredox Catalysis

Author(s) -

Zhou Shupeng,

Zhang Deliang,

Sun Yu,

Li Ruofan,

Zhang Wenhao,

Li Ang

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400702

Subject(s) - chemistry , photoredox catalysis , intermolecular force , radical , conjugate , indole test , catalysis , photochemistry , visible spectrum , combinatorial chemistry , organic chemistry , molecule , photocatalysis , mathematical analysis , physics , mathematics , optoelectronics

We have developed an intermolecular conjugate addition of 3a‐pyrroloindoline/furoindoline radicals to α,β‐unsaturated enones, through visible‐light photoredox catalysis. Ir(ppy) 2 (dtbbpy) PF 6 was found to be an effective promoter to initiate this reaction from readily available 3a‐bromopyrroloindolines/furoindolines. This method was exploited to prepare a series of indole terpenoid‐like compounds of potential biological interest.

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