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Organocatalytic Enantioselective Sulfur‐Michael Addition of Thioacetic Acid to Arylmethylidenemalonates
Author(s) -
Wang Renchao,
Liu Jing,
Xu Jiaxi
Publication year - 2015
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400664
Subject(s) - enantioselective synthesis , chemistry , enantiomer , michael reaction , sulfur , organocatalysis , organic chemistry , enantiomeric excess , catalysis , combinatorial chemistry
An organocatalytic enantioselective sulfur‐Michael addition of thioacetic acid to arylmethylidenemalonates was developed with high yields and up to 97% enantiomeric excess. Both enantiomers of the products were accessible with two different organocatalysts. The current method provides the first, practical, and convenient preparation of enantiomerically enriched acetylthiomethylmalonate derivatives.