Transition Metal‐Free Intermolecular α‐CH Amination of Ethers at Room Temperature | Zendy

Buslov Ivan | Zendy; Hu Xile | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Transition Metal‐Free Intermolecular α‐CH Amination of Ethers at Room Temperature

Author(s) -

Buslov Ivan,

Hu Xile

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400646

Subject(s) - amination , chemistry , hypervalent molecule , reagent , intermolecular force , transition metal , organic chemistry , alkyl , catalysis , combinatorial chemistry , molecule

We describe a new method for the intermolecular amination of the α‐CH bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti‐cancer prodrug Tegafur and its analogues.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research