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Transition Metal‐Free Intermolecular α‐CH Amination of Ethers at Room Temperature
Author(s) -
Buslov Ivan,
Hu Xile
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400646
Subject(s) - amination , chemistry , hypervalent molecule , reagent , intermolecular force , transition metal , organic chemistry , alkyl , catalysis , combinatorial chemistry , molecule
We describe a new method for the intermolecular amination of the α‐CH bonds of ethers. A hypervalent iodine reagent was used as oxidant to enable the amination of cyclic and acyclic alkyl ethers with a wide range of amides, imides, and amines. The amination occurred at room temperature and without a transition metal catalyst. The method could be used to synthesize the anti‐cancer prodrug Tegafur and its analogues.