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Enantioselective Lewis‐Base‐Catalyzed Asymmetric Hydrosilylation of Substituted Benzophenone N ‐Aryl Imines: Efficient Synthesis of Chiral (Diarylmethyl)amines
Author(s) -
Hu XiaoYan,
Zhang MinMin,
Shu Chang,
Zhang YongHong,
Liao LiHua,
Yuan WeiCheng,
Zhang XiaoMei
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400643
Subject(s) - chemistry , benzophenone , lewis acids and bases , enantioselective synthesis , hydrosilylation , catalysis , aryl , base (topology) , organic chemistry , medicinal chemistry , mathematical analysis , alkyl , mathematics
Lewis‐base‐catalyzed asymmetric hydrosilylation of substituted benzophenone N ‐aryl imines was investigated. Among various chiral Lewis‐base catalysts, a catalyst derived from L ‐Serine was found to be the most favorable one which promote the reaction to afford a series of (diarylmethyl)amines with high yields (up to 97 %) in moderate to good enantioselectivities (up to 97 % ee ). The absolute configuration of the product was determined by the X‐ray crystallographic analysis.