Premium
Acylation of Pyrroles and their Free (N‐H)‐Derivatives via Palladium‐Catalyzed Carbopalladation of Nitriles
Author(s) -
Jafarpour Farnaz,
Hazrati Hamideh,
Darvishmolla Masoumeh
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400598
Subject(s) - chemistry , palladium , acylation , regioselectivity , catalysis , hydrolysis , organic chemistry , combinatorial chemistry , palladium catalyst , medicinal chemistry
An efficient regioselective synthesis of 2‐acylpyrroles via palladium‐catalyzed addition of pyrroles with benzonitriles and subsequent hydrolysis is developed. The direct acylation reaction of protected as well as (NH)‐free pyrroles proceeded smoothly to afford 2‐acylpyrrole scaffolds of high biological interest.