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Palladium‐Catalyzed Cross Addition of Terminal Alkynes to Aryl Ynamides: An Unusual trans ‐Hydroalkynylation Reaction
Author(s) -
Liu Ge,
Kong Wei,
Che Jianwei,
Zhu Gangguo
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400572
Subject(s) - chemistry , cycloisomerization , stereoselectivity , catalysis , palladium , alkynylation , enyne , aryl , adduct , naphthalene , sulfonyl , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , alkyl
A palladium‐catalyzed trans ‐hydroalkynylation of N ‐sulfonyl ynamides has been achieved for the first time, providing α‐alkynylation adducts in high yields with excellent regio‐ and stereoselectivity. The resulting enyne products can serve as the useful precursors for the elaboration of naphthalene derivatives via a platinum‐catalyzed cycloisomerization reaction.