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Generation of Ethynyl‐Grignard Reagent in a Falling Film Microreactor: An Expeditious Flow Synthesis of Propargylic Alcohols and Analogues
Author(s) -
Deng Qiulin,
Shen Ruwei,
Ding Rong,
Zhang Lixiong
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400560
Subject(s) - microreactor , chemistry , reagent , flow chemistry , grignard reaction , grignard reagent , bromide , selectivity , organic chemistry , acetylene , combinatorial chemistry , catalysis
We report a falling film microreactor (FFMR) based gas‐liquid continuous microflow process, which features an efficient gas‐liquid reaction in a microreactor for the generation of the ethynyl‐Grignard reagent directly from acetylene gas and ethylmagnesium bromide (EtMgBr). The successful implement of this process leads to an expeditious flow synthesis of propargylic alcohols and analogues with high selectivity.