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Hydroaminomethylation of Olefins with Aminomethyltrifluoroborate by Photoredox Catalysis
Author(s) -
Miyazawa Kazuki,
Koike Takashi,
Akita Munetaka
Publication year - 2014
Publication title -
advanced synthesis and catalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.541
H-Index - 155
eISSN - 1615-4169
pISSN - 1615-4150
DOI - 10.1002/adsc.201400556
Subject(s) - chemistry , primary (astronomy) , photoredox catalysis , catalysis , combinatorial chemistry , photocatalysis , alkene , organic chemistry , physics , astronomy
A photocatalytic hydroaminomethylation of olefins with N ‐protected aminomethyltrifluoroborates has been developed. This methodology provides a new strategy for the introduction of a primary aminomethyl group onto electron‐deficient CC bonds. This reaction constitutes a facile entry into synthetically useful γ‐aminobutyric acid (GABA) derivatives such as baclofen.