A Palladium‐Catalyzed Carbonylative–Deacetylative Sequence to 1,3‐Keto Amides | Zendy

Nielsen Dennis U. | Zendy; Korsager Signe | Zendy; Lindhardt Anders T. | Zendy; Skrydstrup Troels | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A Palladium‐Catalyzed Carbonylative–Deacetylative Sequence to 1,3‐Keto Amides

Author(s) -

Nielsen Dennis U.,

Korsager Signe,

Lindhardt Anders T.,

Skrydstrup Troels

Publication year - 2014

Publication title -

advanced synthesis and catalysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.541

H-Index - 155

eISSN - 1615-4169

pISSN - 1615-4150

DOI - 10.1002/adsc.201400545

Subject(s) - chemistry , catalysis , palladium , carbon monoxide , aryl , carbonylation , sequence (biology) , combinatorial chemistry , organic chemistry , stereochemistry , alkyl , biochemistry

An efficient three‐component reaction involving carbon monoxide with a range of aryl bromides and N ‐substituted acetoacetamides is reported for the synthesis of β‐keto amides. This transformation is promoted by Pd‐catalysis followed by an acid‐mediated deacetylation upon work‐up, enabling a large number of β‐keto amides to be isolated. Finally, d 2 ‐ 13 C‐dyclonine could be synthesized in three steps utilizing the developed catalytic system as the key step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research